Can peptides cause joint pain or worsen osteoarthritis?

BPC-157 and TB-500 are often used to reduce joint pain. However, some users report transient joint discomfort when starting growth hormone peptides due to fluid retention. True worsening of arthritis is uncommon. Persistent pain should be evaluated. <a href='https://www.niams.nih.gov/health-topics/osteoarthritis' target='_blank'>NIAMS Osteoarthritis Info</a>