Is there tolerance to weight loss peptides over time?

Some people experience diminished response after 6-12 months. Switching to a different mechanism (e.g., Semaglutide to Retatrutide) may restore effectiveness. Weight loss typically plateaus after 68 weeks. <a href='https://clinicaltrials.gov/study/NCT04972760' target='_blank'>Long-term efficacy study</a>