What is the difference between Semaglutide and Orlistat for weight loss?

Semaglutide works by reducing appetite (9-15% weight loss), while Orlistat blocks fat absorption (3-5% weight loss). Semaglutide is more effective but requires injections. Orlistat is oral but causes GI side effects. <a href='https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/orlistat-marketed-alli-and-xenical-safety-information' target='_blank'>FDA Orlistat info</a>